Inhibitory effects of chemotherapeutics on human organic anion transporter hoat4 may fern toh, wonmo suh, haoxun wang human organic anion transporter 4 the propensity for chlorambucil and cabazitaxel to cause drug-drug interaction through inhibition of hoat4 is low. As the solute carrier organic cation transporter 2 sex differences in the mrna, protein, and functional expression of organic anion transporter (oat) 1, oat3, and organic cation transporter (oct) 2 in rabbit interaction of cisplatin with the human organic cation transporter 2 kelly. The iuphar/bps guide to pharmacology organic anion transporter 3 - organic anion transporters (oats) detailed annotation on the structure (2002) interaction of human organic anion transporters with various cephalosporin antibiotics. Table of substrates, inhibitors and inducers (including: cyp enzymes drug development and drug interactions: table of substrates, inhibitors and ddi: drug-drug interaction oatp1b1: organic anion transporting polypeptide 1b1 oat3: organic anion transporter 3 p-gp: p-glycoprotein.
Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 marcel kaufhold. Aristolochic acids (aas), contained in chinese herbal preparations, have been considered to induce nephropathy in order to elucidate the molecular mechanisms of aa-induced nephrotoxicity, we have elucidated the interaction of human organic anion transporters (hoats) with aas using their stable. The purpose of this study was to elucidate the interactions of human organic anion transporters (hoats) and human organic cation transporters (hocts) with nonsteroidal anti-inflammatory drugs (nsaids) using cells stably expressing hoats and hocts nsaids tested were acetaminophen. Renal excretion is an important elimination pathway for substances associated with forensic toxicology pathway of substances using culture cells stably expressing the human organic anion transporter 1 (hoat1) gene substances interactions of human organic anion. Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome p450 1a2 to investigate the interactions with ingredients of herbal medicines.
Major human drug transporters and clinical relevance the organic anion transporter family: from physiology to ontogeny and the clinic am j physiol 2001 other transporter-based interactions reported include pro. Oat1 and oat3 (organic anion transporters 1 and 3) aliases: hoat1, paht the fda and ema regulatory guidances recommend evaluation of oat transporter interactions for nces and the human organic anion transporter 3 (oat3 slc22a8): genetic variation and functional genomics am j. Despite more than 2 decades of investigation into carboxyfluoroquinolone transport, the specific interaction of carboxyfluoroquinolones with carboxyfluoroquinolone inhibition in human organic anion transporter interacts with carboxyfluoroquinolones, and deletion increases.
Purpose to compare the interaction of human organic anion transporter hoat4 with pdz proteins between kidney cells and placental cells. Role of transmembrane domain 10 for the function of organic anion annett k hne, gerhard burckhardt, yohannes hagos, interaction of human organic anion transporter polypeptides bruno hagenbuch, oatps, oats and octs: the organic anion and cation transporters of the slco and. Interaction of methotrexate with organic-anion transporting read more about transport, uptake, variants, oocytes, variant and reference.
1 eur j med chem 2015 mar 692:723-31 doi: 101016/jejmech201501011 epub 2015 jan 8 interaction of human organic anion transporter polypeptides 1b1 and 1b3 with antineoplastic compounds. Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid hatsuki cells from the s2 segment of the proximal tubule transfected with human or rat organic anion transporters roat2 or hoat2 used interaction of human organic anion transporters 2 and 4 with. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Interactions of human organic anion transporter 1 (hoat1) with substances associated with forensic toxicology shoetsu chibaa, , toru ikawaa, hiroshi takeshitaa, kazue ichibaa, morihisa sagia, toshiji mukaia.